新型冠状病毒肺炎合并急性肾损伤潜在治疗药物的肾毒性

李若茗, 陈超阳, 马凌云, 李梦雅, 周颖, 崔一民

中国药学杂志 ›› 2020, Vol. 55 ›› Issue (18) : 1481-1486.

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中国药学杂志 ›› 2020, Vol. 55 ›› Issue (18) : 1481-1486. DOI: 10.11669/cpj.2020.18.001
综述

新型冠状病毒肺炎合并急性肾损伤潜在治疗药物的肾毒性

  • 李若茗1,2, 陈超阳1,2, 马凌云1, 李梦雅1,2, 周颖1,2*, 崔一民1,2
作者信息 +

Nephrotoxicity of Potential Therapeutic Agents for COVID-19 Infection with Acute Kidney Injury

  • LI Ruo-ming1,2, CHEN Chao-yang1,2, MA Ling-yun1, LI Meng-ya1,2, ZHOU Ying1,2*, CUI Yi-min1,2
Author information +
文章历史 +

摘要

自新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)爆发以来,国家卫健委、军队前方专家组等制订了多版疾病诊疗方案,其中的药物治疗方案成为了学者们研究和讨论的热点。同时,部分临床医师在重症新冠肺炎患者中发现,急性肾损伤(acute kidney injury,AKI)是患者死亡的一个重要危险因素。COVID-19患者发生AKI的机制尚未明确,可能与病毒感染或药物毒性相关,药物相关AKI直接影响着临床治疗方案的选择和患者的远期预后。笔者针对目前推荐用于治疗COVID-19的磷酸氯喹、洛匹那韦/利托那韦、干扰素-α、利巴韦林、阿比多尔和托珠单抗,讨论药物相关肾损伤,特别是AKI的发生风险、临床病例特点和肾毒性机制,为临床诊疗提供参考。

Abstract

Since the outbreak of coronavirus disease 2019 (COVID-19), the National Health Commission and the expert group of the army have formulated multiple versions of diagnosis and treatment scheme, and drug therapy regimens have become a research hotspot for scholars. Meanwhile, some clinicians found that acute kidney injury (AKI) was an important risk factor in the death of patients with severe COVID 19. The mechanism of AKI in COVID-19 patients is still unclear and the causes may be related to virus infection or drug toxicity. Drug-related AKI directly affects the clinical treatment options and the patient′s long-term prognosis. This article targets interferon-α, lopinavir / ritonavir, ribavirin, chloroquine phosphate, abidol and tocilizumab. This article reviewed potential novel coronavirus pneumonia treatment-related AKI, characteristics of the clinical cases, and mechanisms of renal toxicity, to provide a reference for clinical treatment.

关键词

新型冠状病毒肺炎 / 急性肾损伤 / 抗病毒药物 / 肾毒性

Key words

COVID-19 / acute kidney injury / antiviral drug / nephrotoxicity

引用本文

导出引用
李若茗, 陈超阳, 马凌云, 李梦雅, 周颖, 崔一民. 新型冠状病毒肺炎合并急性肾损伤潜在治疗药物的肾毒性[J]. 中国药学杂志, 2020, 55(18): 1481-1486 https://doi.org/10.11669/cpj.2020.18.001
LI Ruo-ming, CHEN Chao-yang, MA Ling-yun, LI Meng-ya, ZHOU Ying, CUI Yi-min. Nephrotoxicity of Potential Therapeutic Agents for COVID-19 Infection with Acute Kidney Injury[J]. Chinese Pharmaceutical Journal, 2020, 55(18): 1481-1486 https://doi.org/10.11669/cpj.2020.18.001
中图分类号: R969.3   

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